News

The CALYM Carnot Institute Wishes You a Happy New Year!

4/01/2019

BIOFIT: CALYM Represented by FINDMED

28/11/2018

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CHICHE!* the New Program of FINDMED for Innovative French SME’s

28/11/2018

The very small, small and medium-sized French companies which would hesitate to partner with the Carnot institutes of the FINDMED consortium can now take this risk thanks to the CHICHE! program. Indeed, this program offers to finance the first phase of the research project set up between the Carnot institute and the company, up to a € 50,000 per project. The ability of the Carnot institute to conduct the research program is thus evaluated on the basis of jointly defined indicators, during this so-called "feasibility demonstration" (...)

Lymphoma Associated with Breast Implants: LYSA-LYSARC in the Media!

27/11/2018

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“Novimmune Relies on the CeVi Collection to Demonstrate the Efficacy of its Bispecific Antibody”

19/11/2018

To assess the efficacy and the mode of action of NI-1701, Novimmune collaborated with CALYM by relying on the richness and quality of its bank of viable cells, ISO 9001 certified. Discover the article published in the industrial newsletter and on the website of the Carnot network, describing the partnership between the “Microenvironment Cell differentiation, iMmunology And Cancer (MICMAC)” team of CALYM and the Novimmune company ! Please download the article (pdf) (...)

2018 ASH Congress: the Annual Unmissable Event for CALYM Researchers

14/11/2018

CALYM researchers will present their last research results on lymphoma. Four oral communications and thirteen posters were indeed selected. The oral communications are: - "Advanced Untreated Follicular B‐Cell Lymphoma in Need of Systemic Therapy”. F Morschhauser et al.(Session 623, 2/12/18 at 4:45 pm, San Diego Convention Center, Hall AB) - “Follicular Lymphoma Grade 3A Exhibits Pathological and Cytogenetic Diversity, but Similar Prognosis Compared to FL Grade 1‐2 : Pooled Analysis of 1757 Follicular Lymphomas from the PRIMA and (...)

Discover the CALYM Activity Report 2017!

30/10/2018

In the summary of our activity report: - our highlights of the year, - our scientific news, - our projects funded by CALYM owing to the Carnot contribution, - the development of our partnerships. Please download our 2017 CALYM report (.pdf)!

“Human germinal center transcriptional programs are de-synchronized in B cell lymphoma”

15/10/2018

Follicular lymphoma (FL), the second most common adult lymphoma in western countries, is considered as a prototypical germinal center (GC**) B cell lymphoma, with several features that identify the cell of origin (COO) of FL as a GC B cell. In bulk analyses it was shown that most genes expressed in GC B cells were also expressed in FL B cells, suggesting that FL B cells are transcriptionally frozen in a GC B cell state. Since bulk analyses are known to mask the cellular heterogeneity that may be present in GC or FL B cells, the authors (...)

Rendez-Vous Carnot: Come Visit CALYM !

28/09/2018

“The R&D meetings for business” gather each year more than 2800 attendees, innovation project leaders in all economic sectors. Four spaces devoted to Health, Sport, Visual and collaborative design and Car and mobility are proposed in 2018 to discover the latest innovations in these areas, associated and accessible technology platforms of the Carnot network and allow companies to meet experts on site or by appointment. The CALYM Carnot institute that will be in the Health village, will present its R&D offer in the lymphoma (...)

“Human Germinal Center Transcriptional Programs are De-synchronized in B Cell Lymphoma”

19/09/2018

Follicular lymphoma (FL), the second most common adult lymphoma in western countries, is considered as a prototypical germinal center (GC*) B cell lymphoma, with several features that identify the cell of origin (COO) of FL as a GC B cell. In bulk analyses it was shown that most genes expressed in GC B cells were also expressed in FL B cells, suggesting that FL B cells are transcriptionally frozen in a GC B cell state. Since bulk analyses are known to mask the cellular heterogeneity that may be present in GC or FL B cells, the authors (...)

Modulating the Immune System to Treat Patients with Follicular Lymphoma

17/09/2018

For patients treated at the beginning of follicular lymphoma (with a high tumor mass), RELEVANCE is the first major study comparing conventional immuno-chemotherapy treatment to a new combination of 2 drugs based on the modulation of immune system functions : lenalidomide taken orally and rituximab intravenously (also called R²). The study was conducted in 10 countries (France, Belgium, Australia, Canada, Germany, Italy, Japan, Portugal, Spain and the United States) by the Lymphoma Study Association (LYSA) and LYSARC, members of CALYM, (...)

International Workshop on PET in Lymphoma and Myeloma (PILM)

14/09/2018

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World Lymphoma Awareness Day is Tomorrow,...

14/09/2018

World Lymphoma Awareness Day is tomorrow, on15 September 2018! Inform yourself with France Lymphome Espoir and CALYM/LYSA researchers during conferences organized in 18 cities in France! In Lyon, see you at the Rockefeller Faculty of Medecine with Pr. Hervé Gesquières! For more information: http://journeefrancelymphomeespoir.fr/journeeMondiale.html

CALYM Researchers, Speakers at the 2018 ASH Meeting on Lymphoma Biology

20/07/2018

This international event aims at bringing together scientific experts on lymphoma and chronic lymphocytic leukemia to discuss the latest lymphoma fundamental science, address current challenges in the field, establish the highest priorities for investigation, and develop novel therapeutics. In the session dedicated to “Microenvironment Influences in Lymphoma », Karin Tarte, head of UMR 1236 laboratory, member of the CALYM Carnot institute will speak about « Follicular Lymphoma Microenvironment : Role in Pathogenesis and Clinical Impact » (...)

PRIMA-PI: a New Simplified and Easy-to-compute Prognostic Scoring System for Routine Practice in Follicular Lymphoma

28/06/2018

In this study, researchers proposed to rely on bone marrow involvement and measurement of beta2 microglobulin * (ß2m) in the blood to classify these patients into three categories : high risk : ß2m> 3mg / L, intermediate risk : ß2m ≤ 3 mg / L with bone marrow involvement and low risk : ß2m ≤ 3 mg / without bone marrow involvement. They compared, in the cohort of patients from the PRIMA** clinical trial, the scores obtained with this new PRIMA-PI index with those of FLIPI, FLIPI2 and a simplified scoring system recently developed by Press et (...)

LYSA’s RELEVANCE Trial in the Media

19/06/2018

Please, discover the press release on this study, published on the website of ASH and the video made by ecancer! Reference : Franck Morschhauser et al. RELEVANCE : PHASE III EFFICACY AND SAFETY STUDY OF LENALIDOMIDE PLUS RITUXIMAB (R2) VERSUS RITUXIMAB PLUS CHEMOTHERAPY, FOLLOWED BY RITUXIMAB, IN PREVIOUSLY UNTREATED FOLLICULAR LYMPHOMA

Immunotherapy: a New Bispecific Antibody to Treat B-cell Lymphoma and Leukemia

25/05/2018

The most widely used treatment for B-cell lymphomas is CHOP chemotherapy combined with anti-CD20 rituximab antibody. However, 30-60% of indolent patients are resistant to rituximab at baseline and up to 50% of relapse after treatment and become refractory. Researchers at Novimmune SA have developed a new bispecific antibody, NI-1701, targeting CD19 and CD47. CD19 is a transmembrane glycoprotein widely expressed in B cell malignancies including those positive for CD20 or not. CD47 is a ubiquitously expressed protein that mediates a (...)

Discover CALYM’s Communications at the 23rd Congress of EHA!

24/05/2018

Oral Communications - Franck Morschhauser et al. RELEVANCE : PHASE III EFFICACY AND SAFETY STUDY OF LENALIDOMIDE PLUS RITUXIMAB (R2) VERSUS RITUXIMAB PLUS CHEMOTHERAPY, FOLLOWED BY RITUXIMAB, IN PREVIOUSLY UNTREATED FOLLICULAR LYMPHOMA - Olivier Casasnovas et al. FINAL ANALYSIS OF THE AHL2011 RANDOMIZED PHASE III LYSA STUDY COMPARING AN EARLY PET DRIVEN TREATMENT DE-ESCALATION TO A NOT PET-MONITORED STRATEGY IN PATIENTS WITH ADVANCED STAGES HODGKIN LYMPHOMA - Sydney Dubois et al. REFINING DIFFUSE LARGE B CELL LYMPHOMA (...)

23rd Congress of EHA: Results of the RELEVANCE Clinical Study Selected in the Presidential Symposium!

18/05/2018

The 23rd annual congress of the European Hematology Association (EHA) will take place from 14 to 17 June 2018 in Stockholm (Sweeden). The abstract “RELEVANCE: Phase III efficacy and safety of lenalidomide plus rituximab (R2) versus rituximab plus chemotherapy, followed by rituximab, in previously untreated follicular lymphoma”, submitted on the RELEVANCE study, conducted by LYSA-LYSARC was selected in the presidential symposium with five other communications! It will be presented by Franck Morschhauser from Hospital University Centre of (...)

"Preclinical Development of Immunotherapies 2018"

23/04/2018

The objective of this event is to combine the expertise of companies (large groups and SMEs) and laboratories to think about specificities and predictivity that different models can offer, depending on the pathology and targeted strategy of immunotherapy. Business meetings are scheduled in the program, an opportunity for CALYM to meet new potential partners. For more information: https://preclinique-immunotherapies2018.b2match.io/

Come and Discover the R&D Offer of CALYM at the Auvergne-Rhône-Alpes Cancer Research Forum!

21/03/2018

A place to exchange ideas on the major issues facing cancer research, the Forum that brings together more than 600 researchers, clinicians and industry partners, promotes sharing between scientific disciplines and stimulates the emergence of new collaborations. During this 13th edition, CLARA will celebrate its 15th birthday and will reveal its fourth action plan for 2018-2022. In the exhibition space, the CALYM Carnot institute that will have a stand, will present its unique R&D offer for the treatment and diagnosis of lymphoma (...)

The CALYM Carnot Institute and the Institut Roche, Partners to Accelerate Together Research against Lymphoma!

19/03/2018

The CALYM Carnot institute aims at accelerating innovation and its transfer in the lymphoma field, particularly in the translational phase. To transform its discoveries of basic research into clinical applications for the patient, the institute benefits from the financial support of the French government (National Research Agency) andrelies on public-private partnerships it develops with industry and other research and technological organizations. It is in this context that CALYM has come closer to the Institut Roche which missions are (...)

CALYM-IMAGINE workshop: a day rich in interactions!

12/02/2018

How new technologies can help us to develop innovative treatments in lymphomas and primary immune defects? This is the question to which the various speakers tried to answer during this scientifically dense day which allowed in particular to open different perspectives of collaboratiosn between CALYM and IMAGINE. The workshop gathered more than one hundred people including about twenty industrial representatives from big pharmaceutical companies such as: Janssen, Sanofi, Abbvie, Astrazeneca, MSD, Celgene, Roche… The morning session (...)

LYSA Days 2018 (Les Journées du LYSA)

31/01/2018

CALYM will present its last news on 8 February at 5 pm. A stand shared by LYSA, LYSARC, the European Lymphoma Institute and CALYM will show the flagship projects of the four Lyon entities. Among the three prestigious guests, Martine Amiot, leader of the CALYM team “Regulation of Bcl2 and p53 Networks in Multiple Myeloma and Mantle Cell Lymphoma” from the Nantes-Anger Cancer and Immunology Research Center, will speak on “Apoptosis and clinical perspectives”. Ash Alizadeh from Stanford University (USA) will speak on circulating DNA in (...)

HAPPY NEW YEAR 2018!

2/01/2018

CELGENE and LYSARC Provide Update on Phase III RELEVANCE’ Study of REVLIMID® in Combination with RITUXIMAB (R2) for the Treatment of Previously Untreated Patients with Follicular Lymphoma

22/12/2017

Celgene Corporation (NASDAQ: CELG) and the Lymphoma Study Association (LYSA) today announced that the Lymphoma Academic Research Organisation (LYSARC) reported results from a phase III, randomized, open-label, international clinical study (RELEVANCE). Download the press release(.pdf)

CALYM-IMAGINE Workshop 2018

20/12/2017

From CRISPR/CAS9 to single-cell technologies, from liquid biopsies to multi-OMICS today’s swift technological advances in genetics and genomics are currently setting the stage for tomorrow’s revolution in patient care. The aim of this joint CALYM / IMAGINE Carnot workshop is to bring together academic and industrial players to discuss how these genetic advances can be used to develop innovative therapies in lymphoma and primary immune deficiencies. REGISTRATIONS are CLOSED. Please, download the program (...)

“Follicular Lymphoma: Long-Term Efficacy of Rituximab maintenance Persists after Ten Years of Follow-up”

20/12/2017

“When a patient in two who received a first-line immunochemotherapy and rituximab maintenance has not relapsed after ten years, can we still consider that follicular lymphoma is incurable?”, asks Pr. Gilles Salles, president of LYSA, LYSARC and CALYM. Discover all the press release (in French) (.pdf)!

Olivier Hermine nominated at the French Académie des Sciences

15/12/2017

Olivier Hermine is Professor in hematology in the Paris-Descartes University, head of the hematological department at the Necker-Enfant maladies hospital and leader of the CALYM team “Molecular Mechanisms of Hematologic Disorders and Therapeutic Implications” at the Imagine institute Inserm U 116 CNRS ERL 8654. He is also coordinator of the Reference center of mastocytosis (CeRemast). His research interests include lymphoproliferation linked to hepatitis C virus, mantle cell lymphomas and regulation of erythropoiesis. He is co-founder and (...)

”Team in the Spotlight” Prize of the ARC Foundation: the CALYM Team of Michel Cogné Rewarded

7/12/2017

In 2017, the board of directors of the ARC foundation gave the “Team in the spotlight” prize (Prix Equipe à l’honneur) to Michel Cogné, leader of the “Control of the B Cell Immune Response and Lymphoproliferation” team of UMR 7276 - Centre de Biologie et Recherche en Santé of Limoges. This prize rewards his research works on the molecular and cellular mechanisms involved in the regulation of B-cell lymphocytes. These major results on cancer were obtained in the framework of the call for proposals “ARC Foundation labeled programs” (« Programmes (...)

ASH 2017: a strong presence of CALYM researchers!

5/12/2017

Twelve oral presentations, seven posters and one education session will be presented by CALYM researchers mainly from LYSA. Download the details of selected presentations (.pdf) More information about ASH 2017

CALYM at Biofit 2017

15/11/2017

The sixth edition of this event, dedicated to technology transfer, academy-industry collaborations and early stage innovations in the field of life sciences, should gather more than 1,200 attendees from more than 30 countries: academics, TTOs, big pharma, biotech start-ups, investors… CALYM will present its R&D offering in the lymphoma field in order to establish new contacts with industrial partners. For more information: (...)

BIO Europe 2017: CALYM Meets theTranslational Needs of Companies

15/11/2017

A dozen of one-to-one meetings were scheduled for CALYM with essentially biotech companies. The needs they expressed were mostly upstream of the early clinical phase of their products in order to validate for example the proof of concept in the lymphoma, determine the mechanism of action, etc. The research continuum created by CALYM, promoting exchanges between basic and clinical research, is a major asset to accelerate the translational R&D of its (future) partners. CALYM as a one-stop shop, has already begun discussions between (...)

I help research against lymphoma!

15/11/2017

The CALYM Carnot institute set up a few years ago a unique collection in France, the CeVi Collection, gathering biological samples of human viable cells isolated from lymphomas or reactive lymphoid tissues: lymph nodes, spleen and bone marrow. These rare samples, associated with biological and clinical databases, make it possible to CALYM teams to develop new in vitro and in vivo lymphoma models, to study the tumor microenvironment or to identify new blood and tissue biomarkers. The objective isto better understand lymphomas and to develop (...)

CALYM at BIO-Europe 2017: Come Meet Us!

26/10/2017

Largest life science partnering conference in Europe, BIO-Europe attracts nearly 3,700 participants including 1,900 companies from sixty countries. Over 20,000 one-to-one meetings are organized on this occasion. CALYM will present its lymphoma R&D offering to potential industrial partners. Come meet us to discover, among other things, our new proprietary assets in lymphoma! For more information about BIO Europe: (...)

Diffuse Large B-Cell Lymphoma: a New Assay for better Targeted Therapies

24/10/2017

DLBCL is the most common non-Hodgkin’s lymphoma subtype. Depending on the cell from which the disease originates, DLBCL can be classified into three major subtypes determining the prognostic and treatment of patients. Philippe Ruminy and Victor Bobée from the CALYM team of Fabrice Jardin at the Henri Becquerel Centre in Rouen, developed a new diagnostic tool based on the expression profiling of 21 genes allowing to classify DLBCL in germinal center B-cell-like (GCB), activated B-cell-like (ABC), and primary mediastinal B-cell (PMBL) (...)

Bertrand Nadel, New Manager of the CALYM Carnot Institute

17/10/2017

Bertrand Nadel has been actively involved in the life of CALYM since its inception in 2012, as a member of the Scientific Evaluation and Coordination Committee (COSCI) and a member of the Steering Committee (COPIL). "Several waves of conceptual and technological revolutions are on their way to profoundly modify the scientific, medical and socio-economic landscape of oncology, prompting an unprecedented public-private dialogue. I seek to continue my investment and commitment in the development of CALYM, taking up the fantastic challenge (...)

CALYM again ISO 9001 certified

5/10/2017

Following its last quality audits in September in Toulouse, Paris and Lyon, CALYM obtained the renewal of its ISO 9001 certification for the management and monitoring of its research activities and the coordination of its CeVi collection of lymphoma viable cells. Particularity of this year, the changeover to the 2015 version. Explanations... In accordance with the Carnot charter, CALYM undertook in 2012 the implementation of a quality approach in order to: - guarantee the socio-economic partners an optimal level of performance within (...)

Mantle Cell Lymphoma: an Immunotherapy after Chemotherapy Prolongs Patients Survival

3/10/2017

Addition of rituximab immunotherapy after chemotherapy in patients with mantle cell lymphoma prolonged their survival, according to a study conducted by the French and Belgian centers of the Lymphoma Study Association (LYSA) and published on 27 September 2017 in the New England Journal of Medicine (NEJM)*. Download the press release (in french) (.pdf) * : S. Le Gouill et al., Rituximab after Autologous Stem-Cell Transplantation in Mantle-Cell Lymphoma, N Engl J Med 2017 ; 377 (...)

Discover the CALYM 2016 activity report!

29/09/2017

Download report (.pdf)

Presentation of the CALYM Lymphoma Viable Cell Collection at the 3rd CRCL International Symposium

6/09/2017

This event aims at gathering clinicians and scientists to address fundamental issues of cancer biology from the molecular and biochemical determinants of cancer initiation and dissemination, to the impact of the tumor microenvironment and immunity. Interactions between basic, clinical, and translational research will be particularly emphasized. The program is divided into four sessions: - cancer cell plasticity, - immunity and virus in cancer, - tumor microenvironment, - innovative therapies. For each of these sessions, international (...)

CALYM at the “Nordic Life Science Days” business convention

31/08/2017

With more than 1000 participants at the last edition, this business convention is the largest of Northern Europe. More than 2200 one-to-one meetings are expected between representatives of pharma, biotech and medtech companies, CROs, academics and investors. CALYM will present its lymphoma R&D offer. For more information: https://www.nlsdays.com/

World Lymphomas’ Day – 15 September, 2017

23/08/2017

Let’s meet in 21 cities in France! The France Lymphome Espoir association supported among others by LYSA, is organising an information day in 21 cities in France on Friday 15 September, 2017. It is open to anyone. The objective of the day is to inform about the pathology, to give the opportunitiy to meet doctors, medical staff and to discuss & share questions and hopes with patients, their close relatives and the association volunteers. Registration is recommended. More information at (...)

Carnot: Research for Companies

28/07/2017

https://youtu.be/CeDhHMs8ZyE

Focus on Health at the Rendez-Vous Carnot 2017

26/07/2017

For this 10th edition, the Rendez-Vous Carnot offer several thematic focuses including for the first time health with a dedicated space gathering the Carnot and associated Carnot institutes in this field: CALYM, Curie-Cancer, France Futur Elevage, Institut du Cerveau et de la Moelle Epinière - ICM, Imagine, Voir & Entendre, Pasteur MS. The FINDMED Carnot “Health-medicines” project will also be present in that space as the Medicen competitive cluster. The complete R&D offer of each player will be exhibited, the opportunity for life (...)

ICML 2017: a Strong Presence of CALYM Researchers

26/07/2017

This year the LYSA representation was exceptional as 16 LYSA papers were selected for an oral presentation (out of a total of 140). Among them, two studies presented new genic expression assays. Philippe Ruminy from the Inserm U1235 team of Rouen, member of CALYM, presented a RT-MLPA based assay allowing to identifying major peripheral T-cell lymphoma sub-types with 20 markers. Bruno Tesson, a CALYM bioinformatician, contributed to the results presented by Sarah Huet from Lyon Hospital (Hospices Civils de Lyon) on an assay based on the (...)

Tazemetostat, a New Step in the Development of this Fist-in-class Drug, Tested in a LYSARC Trial

30/05/2017

The CALYM Carnot institute and LYSARC are proud to count Epizyme as one of their partners as the U.S. Food and Drug Administration (FDA) has granted Fast Track status to their first-in-class EZH2 inhibitor, tazemetostat, as a potential treatment for relapsed or refractory follicular lymphoma patients with or without EZH2 activating mutations. Fast Track status allows fostering and accelerating the development of important new drugs under study, making them available to patients more quickly. It is a good news as LYSARC is evaluating the (...)

Launch of the Lymphoma Academy

22/05/2017

The Lymphoma Academy, a LYSARC initiative, is a scientific and operational lymphoma training offer. It leverages the long-standing experience and expertise developed by the entities that form together the “Lymphoma Cluster”: - the CALYM Carnot institute, - The Lymphoma Academic Research Organisation (LYSARC), - The Lymphoma Study Association (LYSA), - The European Lymphoma Institute (ELI). It is now available on the web platform www.thelymphomacademy.orgfor all staff or members of the Lymphoma Cluster. In the future it will be (...)

Discover the New CALYM Brochure!

19/05/2017

The CALYM Carnot institute is happy to present its new presentation brochure. Please, download it (.pdf)!

CALYM at BIO 2017: Already Take your Appointment!

16/05/2017

CALYM R&D offer devoted to lymphoma, from the elucidation of the mechanisms of action of new molecules, to the identification of new biomarkers and to Phase III clinical studies, will be presented during face-to-face meetings. This exceptional international event predicts for this edition more than 35,000 one-to-one meetings with more than 3,100 companies! The opportunity for CALYM to link new partnerships! More information about BIO: (...)

CALYM at the MEET2WIN National Oncology Business Convention

9/05/2017

MEET2WIN plans this year to bring together more than 200 participants: representatives of big pharma & diagnostic companies, biotechs, startups, researchers, clinicians, TTO’s, investors etc. Organized around one-to-one meetings, the convention aims at boosting collaborations opportunities between public and private sectors. The CALYM Carnot institute will present its R&D offer to future potential partners during one-to-one meetings of which more than ten are already pre-scheduled. In addition to one-to-one business meetings, (...)

Laying the Foundation Stone for the CENS-ELI Building

19/04/2017

The earthworks for the new CENS-ELI building have recently begun. This construction will enable the research and / or training activities of CENS (Centre for European Nutrition and Health) on the one hand and ELI (European Lymphoma Institute) on the other. ELI will bring together LYSARC, LYSA and the CALYM Carnot institute. The € 15 million cost is financed by LYSARC (€ 3 million), the city of Lyon and the Auvergne-Rhône-Alpes region. The ceremony to lay the foundation stone is scheduled for 24 April 2017 at 9:30 am in the presence (...)

CALYM at the Auvergne-Rhône-Alpes Cancer Research Forum

28/03/2017

A place to exchange ideas on the major issues facing cancer research, the Forum that brings together each year 500 researchers, clinicians and industry partners, promotes sharing between scientific disciplines and stimulates the emergence of new collaborations. The CALYM Carnot institute that will have a stand, will present its unique R&D offer and the lymphoma cluster. The latter gathers LYSA (The Lymphoma Study Association), a cooperative group, international leader of lymphoma research, LYSARC (the Lymphoma Academic Research (...)

Make an appointment with CALYM at BIO-Europe Spring!

14/03/2017

More than 2,400 professionals from more than 1,400 companies from 45 countries will attend this life science unmissable event in Europe. More than 12,500 face-to-face meetings are scheduled. CALYM will take the opportunity to present its unique R&D offer in the lymphoma field. For more information: https://ebdgroup.knect365.com/bioeurope-spring/

Epigenetics & Cancer: SAVE THE DATE!

12/03/2017

DEADLINE FOR ABSTRACT SUBMISSION: 31 MARCH 2017! The conference is organized by 4 institutions and research team networks, CVT AVIESAN, Institut Curie, REpiCGO and Grenoble Epigenetics Club, which are highly involved in epigenetics basic and translational research. The goal is to bring together leading scientists, clinicians and companies interested in epigenetics to discuss the latest discoveries and development of their applications in cancer therapy and diagnosis. The first day will focus on the new insights in epigenetic (...)

Discover our lymphoma biomarkers research and development offer!

24/02/2017

According to its partners’ needs, CALYM offers to carry out the research and co-development of lymphoma biomarkers in this way: CALYM (and possibly its industrial partners): - carries out the biomarker discovery phase and establishes the proof of concept - transfers the biomarker/the technology - carries out the clinical validation phase CALYM’s partner (in vitro diagnosis, biotechnology, pharmaceutical company) - products and qualifies analytically the assay (kit) - obtains the CE marking authorization - carries out the (...)

Discover the Presentation Booklet of CALYM’s Teams!

23/01/2017

A new presentation booklet for the 15 entities of CALYM is now available for download. Download the booklet (.pdf)!

Kick-off of the European Project HARMONY

9/01/2017

HARMONY : “Healthcare Alliance for Resourceful Medicines Offensive against Neoplasms in HematologY” is a European network of excellence funded by “The Innovative Medicines Initiative in the amount of € 40M. This project, made up of 51 academic and industrial partners from 11 European countries aims to create a roadmap for better access and care for patients with various blood diseases with the use of big data. With HARMONY, a more rapid detection of promising treatment strategies and prediction of their potential adverse events will be (...)

Latest News from ASH 2016 on Lymphomas in Videos

21/12/2016

- Pr. Thierry Lamy from Rennes University Hospital and U917 Inserm team on non-Hodgkin lymphomas: https://www.youtube.com/watch?v=xmEPc3xz48A - Richard Delarue, from Necker Hospital from Paris on Hodgkin lymphomas: https://www.youtube.com/watch?v=Ds6S4seYkyI These videos were produced by the France Lymphoma Espoir patient association: (...)

The Team of Bertrand Nadel Rewarded by the ARC Foundation

24/11/2016

Research works of Bertrand Nadel are part of the call for projects "ARC Foundation Labeled Programs". They will ultimately lead to a better diagnosis and a more effective treatment of follicular lymphoma. These studies are based on a large cohort of individuals (EPIC) in order to identify the factors associated with the (14, 18) translocation leading to the occurrence of this cancer in some patients. Download the press release (...)

CALYM researchers at the ASH meeting

15/11/2016

This world’s premier event in malignant and non-malignant hematology gathers more than 20,000 hematology professionals. Several CALYM researchers, members of LYSA, will present their last clinical research results in 8 oral communications and 9 posters. Moreover, an education program will be presented by Bertrand Coiffier on "Diffuse Large B Cell Lymphoma: R-CHOP Failure - What to Do?". Of the 8 oral communications, 4 are highlighted by the ASH as "clinically relevant": - N°145: Rituximab maintenance after autologous tem cell (...)

CALYM at the R2B of the CLARA Cancer Research Cluster

15/11/2016

The CLARA Cancer Research Cluster organizes the Research2Business Oncology Meeting in Lyon on 15 November 2016, its business convention dedicated to collaborative R & D, technology transfer and open-innovation in the field of oncology. CALYM will be present to present its partnership offer. For more information: http://www.canceropole-clara.com/manifestations/research-2-business-oncology-meeting-2016-accueil/

CALYM’S 3rd SCIENTIFIC & PARTNERING DAY - Presentations

28/10/2016

CALYM’s 3rd SCIENTIFIC & PARTNERING DAY, took place October 17, 2016 in Paris. CALYM researchers and clinicians presented the new lymphoma R&D offering and highlight research results of the consortium, from new therapeutic targets identification to Phase III pivotal clinical trials and beyond. More than 110 people including 36 industry representatives, from pharmaceutical, biotechnology, diagnosis and imaging companies were present such as ABBVIE, BAYER, BioOncology Genentech, Boehringer Ingelheim, CELGENE, GILEAD, IPSEN, JANSSEN, (...)

BIO-Europe 2016: take appointment with CALYM!

27/10/2016

Largest life science partnering conference in Europe, BIO-Europe attracts over 3,600 participants including 1,900 companies from sixty countries. Over 20,000 one-to-one meetings are organized on this occasion. CALYM will present its new lymphoma R&D offering,from new therapeutic targets identification to Phase III pivotal clinical trials, as part of its new scope following its "Carnot 3" accreditation granted by the French Ministry of Research and higher education. For more information about BIO Europe: (...)

1st Annual European Congress on Hematology : Focus on Lymphoid Malignancies – Paris Lymphomas

14/10/2016

Mr. Gilles Salles, president of CALYM is co-chair of the program of this international highly practical and interactive event which objectives are to improve patient care for the clinician who manages patients with lymphoid malignancies. Registrations: http://www.gotoper.com/europe Download the program (.pdf)

CALYM’S 3rd SCIENTIFIC & PARTNERING DAY

12/10/2016

SOME PLACES ARE STILL AVAILABLE! CALYM’s 3rd SCIENTIFIC & PARTNERING DAY, will take place next October 17, 2016 in Paris, Espace Van Gogh, 62, quai de la Rapée. CALYM researchers and clinicians will be happy to present the new lymphoma R&D offering and highlight research results of the consortium, from new therapeutic targets identification to Phase III pivotal clinical trials and beyond. IPSEN and CELGENE representatives will bring industry standpoint. PLEASE DOWNLOAD OUR PROGRAM! This meeting offers for pharma, (...)

CALYM at the RDV Carnot 2016

4/10/2016

CALYM will be present at the RDV Carnot from October 5 to 6, 2016 at the Espace Double-Mixte in Villeurbanne. The R&D offering of the institute devoted to lymphoma will be presented at the stand E22. Come and visit us! For more information: http://www.rdv-carnot.eu/

CALYM at the LYSA Days - October 6 to 8 2016

29/09/2016

LYSA (The Lymphoma Study Association) Days will be held from 6 to 8 October 2016 at the Lyon Convention Center. Every 18 months, those days are a time of exchange between professionals involved in the life of the association. It will be again this year the opportunity to share all the scientific information about advances in the understanding and treatment of lymphomas. A stand grouping the 4 major players in lymphoma R & D: LYSA, LYSARC (The Lymphoma Research Clinical Organisation), ELI (The European Lymphoma Institute) and (...)

6th International Workshop on PET in Lymphoma

15/09/2016

The 6th International Workshop dedicated to PET in the Lymphoma field will take place from September 20th to 21st in Menton, France. CALYM is partner of this event. At the program, a dedicated session to PET and other imaging techniques in Myeloma, another session focused on PET in T cell lymphoma. A third session will present clinical issues of quantitative measurement of PET parameters (Q-PET) and a large part of this session will be devoted to discussions on this burning topic. Preliminary data from new imaging modalities such as (...)

September 15, 2016: World Lymphoma Awareness Day

14/09/2016

The World Lymphoma Awareness Day,organized in France by the patients’ association France Lymphome Espoir, under the aegis of the Lymphoma Coalition is an opportunity to remember that lymphoma is still unknown by the general public while it is increasingly widespread. More than 1,000,000 people around the world live with lymphoma and 1,000 are diagnosed every day. Many patients do not know their subtype whereas lymphoma has more than 60 subtypes with their specificities and associated treatments. This day is an opportunity for the (...)

"Lymphoma Translational Research: some Highlights from CALYM Institute" symposium

7/09/2016

The CALYM Carnot Institute organizes on September 13th at the Imagine Institute (Necker Hospital, Paris 15) a symposium on the occasion of the visit in France in the laboratory of Philippe Gaulard (Mondor Institute of Biomedical Research), of Pr. Tak W. Mak, from the Campbell Family Institute for Breast Cancer Research at Princess Margaret Cancer Centre (University Health Network, Toronto, Canada). He will speak about "Anti PLK4 and anti TTK inhibitors", two new drugs that his team recently developed and which could have applications in (...)

2016 ASH Meeting on Hematologic Malignancies

8/08/2016

This annual international meeting brings together more than 600 hematology professionals from more than 30 countries, including clinicians, clinical researchers, and fellows. The majority of the program content will be structured as "How I Treat" sessions on core malignancies, including lymphoma, leukemia, myeloma, etc. Key date Advance Registration Deadline: August 22, 2016 For more information: (...)

CALYM’S 3rd SCIENTIFIC & PARTNERING DAY

29/07/2016

CALYM’s 3rd SCIENTIFIC & PARTNERING DAY, will take place next October 17, 2016 in Paris, Espace Van Gogh, 62, quai de la Rapée. CALYM researchers and clinicians will be happy to present the new lymphoma R&D offering and highlight research results of the consortium, from new therapeutic targets identification to Phase III pivotal clinical trials and beyond. IPSEN and CELGENE representatives will bring industry standpoint. PLEASE DOWNLOAD OUR PROGRAM! This meeting offers for pharma, biotech, diagnostics and imaging (...)

October 17, 2016: SAVE THE DATE!

12/07/2016

Please note: Marc de Garidel, MSc, MBA, Chairman & CEO of Ipsen and Vice-President of "The European Federation of Pharmaceutical Industries and Associations" will talk about "Industry-Academia Lifescience Research Partnering: Why and How?".

Henceforth, follow CALYM onTwitter @CarnotCALYM!

6/07/2016

CALYM at the 17-20 of Carnot institutes

6/07/2016

Companies, laboratories, institutions, actors of research and innovation will meet and exchange on the theme "Industrial transformation through innovation." The 8 actions “Carnot filières” (chains) set up in the fields of: Manufacturing, Medicine, Extractive industries and primary processing, Aeronautics, Automotive and mobility, Fashion & Luxury, Sport and wellness, Energy, will be exhibited. CALYM, partner of the medicine Carnot sector, FINDMED will be represented. FINDMED is carried by 6 Carnot institutes dedicated to health (...)

Article on CALYM: « Advancing Innovation in Lymphoma »

16/06/2016

Discover the latest article presenting CALYM and its partnership offer in the lymphoma field, published in Nature BioPharma Dealmakers! Please visit https://biopharmadealmakers.nature.com/users/15869-calym/documents/6574-calym-profile-june-2016

28th EORTC-NCI-AACR Symposium

15/06/2016

The 28th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics will take place in Munich, Germany from 29 November to 2 December, 2016. This international meeting, focusing on preclinical and phase I studies will bring together academics, scientists and pharmaceutical industry representatives to discuss the latest innovations in drug development, target selection and the impact of new discoveries in molecular biology. The event will also focus on experimental models for cancer detection, diagnosis and treatment. (...)

FAID 2016 - Precision Medicine&new technologies: transforming clinical research

12/01/2016

FAID 2016 - PRECISION MEDICINE & NEW TECHNOLOGIES: TRANSFORMING CLINICAL RESEARCH February 9&10, 2016 MIT Media Lab, 75 Amherst St, Cambridge, MA The topic of the 2016 edition is “Precision Medicine & New Technologies: Transforming Clinical Research”. This conference is organized by the Office for Science & Technology of the Embassy of France in the United States in collaboration with MIT and the Global Care Initiative, a consortium of 5 non-profit French research Carnot Institutes. About FAID (...)