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From Bench to Bedside

From Lymphoma Biology…

Biological rationale

- Mantle cell lymphoma (MCL) biology and molecular regulation

- Focus on B-cell-receptor signaling, apoptosis and microenvironement

Preclinical study

- Relevant human ex vivo model for primary MCL cells

- New insights for survival and drug resistance

…To Phase I Clinical Trial

Clinical study

- OAsIs trial: Phase I (sponsor: CHU de Nantes ) - NTC#02558816

- Treatment regimen at the forefront of research with the association of 3 drugs

- Highly collaborative with 3 international pharmaceutical companies and 4 medical centers (France & UK)

References

Chiron D et al. Rational targeted therapies to overcome microenvironment-dependent expansion of mantle cell lymphoma. Blood (2016). DOI:10.1182/blood-2016-06-720490

Oral presentation: American Society Hematology Annual Meeting 2016

Poster: 2016 ASCO Annual Meeting